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New Aspects of Antidepressants

Depression is a common and severe illness, and its relevance and priority for health care is also supported by the availability of effective treatments. Every year, the number of active biological substances that are used in the treatment of depression increases, the amount of information about their mechanisms of action, effectiveness and safety, and peculiarities of use in different groups of patients grows. In this article we will talk about New Aspects of Antidepressants.

The use of antidepressants

The use of antidepressants is currently the most common method of treating various disorders of the depressive spectrum. They include not only classical variants of endogenous depression, but also its erased and atypical forms. In addition, in recent years, the effectiveness of antidepressants has been found in a number of syndromes and disorders whose affective nature is questionable. These include:

  • obsessive-compulsive, panic, anxiety disorders, including agoraphobia and social phobia;
  • post-traumatic stress disorder;
  • somatoform disorders;
  • bulimia nervosa;
  • narcolepsy;
  • enuresis and some other conditions.

The mechanism of action of antidepressants in all these conditions remains poorly understood, but in many cases it seems to be related to the polyvalence of biological action of the drugs. It is believed that the pathogenesis of depression is based on the dysregulation in the central monoaminergic systems. Antidepressants that inhibit monoamine reuptake are widely used in the clinic to relieve the symptoms of depression. However, emerging evidence suggests that many antidepressants not only inhibit monoamine reuptake but also have other mechanisms of action.

Mechanism of Action and Specific Effects of Antidepressants

Initially, antidepressants were used to treat depression, but due to their long-term use, it has been found that they can also effectively influence other syndromes that result from mental, neurological, as well as somatic diseases.

Depression is a common mood disorder that is accompanied by behavioral and cognitive symptoms such as sleep and eating disorders, loss of interest, loss of pleasure (anhedonia), decreased energy, feelings of guilt, helplessness, worthlessness and general emotional instability. More than 75% of depressed patients may have chronic pain syndrome, and patients who suffer from chronic pain syndrome of various origins have a predisposition to develop depression.